Children who take over-the-counter cold medications may experience dried-out respiratory passages and thickened nasal secretions. Overuse of nasal decongestants can lead to a “rebound effect” in which the drug becomes less potent and nasal congestion begins to worsen. Other potential side effects associated with cold medications include:
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Drug or other interactions with cold medications
Parents should consult their child’s pediatrician before giving the child any additional prescriptions, over-the-counter medications, nutritional supplements or herbal medications. Substances that may preclude the use of decongestants or antihistamines include:
- Anticholinergic drugs (used for abdominal or stomach spasms or cramps)
- Antidepressants
- Central nervous system (CNS) depressants, including alcohol
- Digitalis glycosides (heart medication)

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